Investigating the Human Genome (PATRICIA BLAIR's Library) by Moyra Smith

Investigating the Human Genome (PATRICIA BLAIR's Library) by Moyra Smith

Author:Moyra Smith
Language: eng
Format: epub
Publisher: FT Press
Published: 2010-06-23T16:00:00+00:00


Molecular-based treatment design in Alzheimer’s disease

Neprilysin is an endopeptidase that is expressed in a number of different tissues, including the brain. Studies on mouse tissues revealed that tissue-specific transcripts are generated and that transcripts in neurons, oligodendrocytes, and kidneys each differ with respect to the exons they contain (Iwata, et al., 2001). Studies on mice hemizygous for neprilysin deficiency revealed increased brain amyloid Abeta42 levels. Evidence also indicates that neprilysin levels are decreased in Alzheimer’s disease and that neprilysin levels are negatively correlated with amyloid levels. Wang, et al. (2010), proposed that measures that increase neprilysin levels might constitute a pathway to Alzheimer’s disease treatment.



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